USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P05787 USC-OGP 2-DE database:  P05787 P05787 General information about the entry View entry in simple text format Entry name K2C8_HUMAN Primary accession number P05787 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Keratin, type II cytoskeletal 8; AltName: Full=Cytokeratin-8; Short=CK-8; AltName: Full=Keratin-8; Short=K8; AltName: Full=Type-II keratin Kb8;. Gene name Name=KRT8 Synonyms=CYK8 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1155: pI=5.46; Mw=52976 SPOT OGP-1156: pI=5.57; Mw=52478 SPOT OGP-1161: pI=5.44; Mw=49904 SPOT OGP-1189: pI=5.12; Mw=42209 Cross-references UniProtKB/Swiss-Prot P05787; K2C8_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name K2C8_HUMAN Primary accession number P05787 Secondary accession number(s) A8K4H3 B0AZN5 F8VXB4 Q14099 Q14716 Q14717 Q53GJ0 Q6DHW5 Q6GMY0 Q6P4C7 Q96J60 Sequence was last modified on  January 23, 2007 (version 7) Annotations were last modified on  March 15, 2017 (version 205) Name and origin of the protein Description RecName: Full=Keratin, type II cytoskeletal 8; AltName: Full=Cytokeratin-8; Short=CK-8; AltName: Full=Keratin-8; Short=K8; AltName: Full=Type-II keratin Kb8; Gene name Name=KRT8 Synonyms=CYK8 Encoded on Name=KRT8; Synonyms=CYK8 Keywords Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycoprotein; Host-virus interaction; Intermediate filament; Isopeptide bond; Keratin; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M34482; AAA35763.1; -; Genomic_DNA EMBL M34225; AAA35748.1; -; mRNA EMBL X74929; CAA52882.1; -; mRNA EMBL X74981; CAA52916.1; -; Genomic_DNA EMBL U76549; AAB18966.1; -; mRNA EMBL AK290938; BAF83627.1; -; mRNA EMBL AK310257; -; NOT_ANNOTATED_CDS; mRNA EMBL AK315826; BAF98717.1; -; mRNA EMBL AK222941; BAD96661.1; -; mRNA EMBL AC107016; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471054; EAW96653.1; -; Genomic_DNA EMBL BC000654; AAH00654.3; -; mRNA EMBL BC063513; AAH63513.2; -; mRNA EMBL BC073760; AAH73760.1; -; mRNA EMBL BC075839; AAH75839.1; -; mRNA EMBL M26512; AAA51542.1; -; mRNA EMBL X12882; CAA31376.1; -; mRNA EMBL X98614; CAA67203.1; -; mRNA CCDS CCDS58234.1; -. [P05787-2]; . CCDS CCDS8841.1; -. [P05787-1]; . PIR A34720; A34720; . RefSeq NP_001243222.1; NM_001256293.1. [P05787-1]; . RefSeq NP_002264.1; NM_002273.3. [P05787-1]; . UniGene Hs.533782; -; . UniGene Hs.708445; -; . ProteinModelPortal P05787; -; . SMR P05787; -; . BioGrid 110054; 53; . DIP DIP-424N; -; . IntAct P05787; 45; . MINT MINT-256526; -; . STRING 9606.ENSP00000293308; -; . DrugBank DB00031; Tenecteplase; . iPTMnet P05787; -; . PhosphoSitePlus P05787; -; . SwissPalm P05787; -; . UniCarbKB P05787; -; . BioMuta KRT8; -; . DMDM 90110027; -; . SWISS-2DPAGE P05787; -; . EPD P05787; -; . PaxDb P05787; -; . PeptideAtlas P05787; -; . PRIDE P05787; -; . TopDownProteomics P05787-1; -. [P05787-1]; . TopDownProteomics P05787-2; -. [P05787-2]; . DNASU 3856; -; . Ensembl ENST00000293308; ENSP00000293308; ENSG00000170421. [P05787-1]; . Ensembl ENST00000546897; ENSP00000447402; ENSG00000170421. [P05787-1]; . Ensembl ENST00000552150; ENSP00000449404; ENSG00000170421. [P05787-2]; . Ensembl ENST00000552551; ENSP00000447566; ENSG00000170421. [P05787-1]; . GeneID 3856; -; . KEGG hsa:3856; -; . UCSC uc001sbd.3; human. [P05787-1]; . CTD 3856; -; . DisGeNET 3856; -; . GeneCards KRT8; -; . H-InvDB HIX0026255; -; . H-InvDB HIX0034365; -; . H-InvDB HIX0168895; -; . HGNC HGNC:6446; KRT8; . HPA CAB000131; -; . HPA CAB001696; -; . HPA HPA049866; -; . MalaCards KRT8; -; . MIM 148060; gene; . MIM 215600; phenotype; . neXtProt NX_P05787; -; . OpenTargets ENSG00000170421; -; . PharmGKB PA30234; -; . eggNOG ENOG410IG4R; Eukaryota; . eggNOG ENOG410YY6B; LUCA; . GeneTree ENSGT00760000118796; -; . HOVERGEN HBG013015; -; . InParanoid P05787; -; . KO K07605; -; . OMA IKGQRAN; -; . OrthoDB EOG091G09KR; -; . PhylomeDB P05787; -; . TreeFam TF317854; -; . Reactome R-HSA-6805567; Keratinization; . Reactome R-HSA-6809371; Formation of the cornified envelope; . SignaLink P05787; -; . SIGNOR P05787; -; . ChiTaRS KRT8; human; . GeneWiki Keratin_8; -; . GenomeRNAi 3856; -; . PMAP-CutDB P05787; -; . PRO PR:P05787; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000170421; -; . ExpressionAtlas P05787; baseline and differential; . Genevisible P05787; HS; . GO GO:0016327; C:apicolateral plasma membrane; IEA:Ensembl; . GO GO:0005911; C:cell-cell junction; IEA:Ensembl; . GO GO:0043034; C:costamere; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005882; C:intermediate filament; IDA:BHF-UCL; . GO GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA; . GO GO:0045095; C:keratin filament; IEA:Ensembl; . GO GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; . GO GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0042383; C:sarcolemma; IEA:Ensembl; . GO GO:0030018; C:Z disc; IEA:Ensembl; . GO GO:0097110; F:scaffold protein binding; IPI:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IEA:InterPro; . GO GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Ensembl; . GO GO:0070268; P:cornification; TAS:Reactome; . GO GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl; . GO GO:0031424; P:keratinization; TAS:Reactome; . GO GO:0051599; P:response to hydrostatic pressure; IEA:Ensembl; . GO GO:0051707; P:response to other organism; IEA:Ensembl; . GO GO:0045214; P:sarcomere organization; IEA:Ensembl; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . InterPro IPR001664; IF; . InterPro IPR018039; Intermediate_filament_CS; . InterPro IPR032444; Keratin_2_head; . InterPro IPR003054; Keratin_II; . InterPro IPR009053; Prefoldin; . PANTHER PTHR23239; PTHR23239; 1; . Pfam PF00038; Filament; 1; . Pfam PF16208; Keratin_2_head; 1; . PRINTS PR01276; TYPE2KERATIN; . SMART SM01391; Filament; 1; . SUPFAM SSF46579; SSF46579; 1; . PROSITE PS00226; IF; 1; .

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